The metabolic milieu of metastases

William J Sullivan; Heather R Christofk

doi:10.1016/j.cell.2015.01.023

The metabolic milieu of metastases

Cell. 2015 Jan 29;160(3):363-4. doi: 10.1016/j.cell.2015.01.023.

Authors

William J Sullivan¹, Heather R Christofk²

Affiliations

¹ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: hchristofk@mednet.ucla.edu.

PMID: 25635452
DOI: 10.1016/j.cell.2015.01.023

Abstract

To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and miR-551a expression, which derepresses creatine kinase expression and allows energy to be captured from extracellular ATP through generation and import of phosphocreatine.

Publication types

Comment

MeSH terms

Animals
Colorectal Neoplasms / metabolism*
Humans
Liver Neoplasms / secondary*
Male
MicroRNAs / metabolism*
Neoplasm Metastasis / genetics*

Substances

MIRN-551 microRNA, human
MIRN483 microRNA, human
MicroRNAs