If you lose your nerves, at least you will not get kidney fibrosis!

Kidney Int. 2015 Feb;87(2):275-7. doi: 10.1038/ki.2014.327.


Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fibers are involved via norepinephrine and α2-adrenergic receptors as well as calcitonin gene-related peptide (CGRP) and its receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Denervation*
  • Kidney / blood supply*
  • Kidney / innervation*
  • Male
  • Reperfusion Injury / prevention & control*