Circulating biomarkers of tolerance

Transplant Rev (Orlando). 2015 Apr;29(2):68-72. doi: 10.1016/j.trre.2015.01.003. Epub 2015 Jan 14.


On the basis of reviewed literature here we describe models of tolerance and summarize the evidence of circulating biomarkers suitable for the assessment of immunological risk in organ transplantation. We focused on results of evaluation of specific peripheral immune cell populations and transcripts in peripheral blood of operationally tolerant liver and kidney transplant recipients. Validation of described markers to define potentially tolerant patients before their use in clinical trials is critical.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • B-Lymphocyte Subsets / physiology*
  • Biomarkers / blood*
  • Humans
  • Kidney Transplantation / adverse effects*
  • Liver Transplantation / adverse effects*
  • Monitoring, Immunologic
  • T-Lymphocyte Subsets / physiology*
  • Transplantation Tolerance / physiology*


  • Biomarkers