Factors contributing to the duration of untreated prodromal positive symptoms in individuals at ultra-high risk for psychosis

Schizophr Res. 2015 Mar;162(1-3):64-6. doi: 10.1016/j.schres.2015.01.013. Epub 2015 Jan 28.


Individuals at ultra-high risk (UHR) for psychosis experience a considerable delay before appropriate clinical attention is provided. Therefore, we investigated the correlates of this delay by examining clinical, socio-demographic and neuropsychological contributors to the duration of untreated prodromal positive symptoms (DUPP) in them (n=73). The slowly progressive mode of functional decline, defined as a small percentage drop in the Global Assessment of Functioning (GAF) score within the past year, and male gender, explained a considerable portion of the DUPP in the multivariate regression model (F=9.269, p<0.001). Slower functional decline may be correlated with delayed care during the UHR period.

Keywords: Delayed care; Duration of untreated prodromal positive symptoms; Functional decline; Psychosis; Ultra-high risk for psychosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease Progression
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Models, Psychological
  • Multivariate Analysis
  • Neuropsychological Tests
  • Prodromal Symptoms*
  • Prospective Studies
  • Psychotic Disorders / epidemiology
  • Psychotic Disorders / psychology*
  • Psychotic Disorders / therapy*
  • Regression Analysis
  • Risk
  • Time-to-Treatment
  • Young Adult