Aging and DNA methylation

BMC Biol. 2015 Jan 31:13:7. doi: 10.1186/s12915-015-0118-4.


In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging / genetics*
  • Animals
  • Cellular Senescence
  • DNA Methylation / genetics*
  • Disease / genetics
  • Humans
  • Organ Specificity / genetics
  • Stem Cells / metabolism