As another publishing year come to a close at the Journal of Medical Systems, it is clear that as a scientific community, the need for a more detailed understanding of the impact of medical systems has never been greater. Technologies that were emerging just a short time ago including radio frequency identification (RFID), wireless body area networks (WBAN), and telecare medicine information systems (TMIS) are now ubiquitous. Additionally, closed-loop controller systems have gained regulatory approval in many settings. As the complexity of these medical systems grow, so to do the challenges of ensuring we have secure, efficient, and reliable systems that integrate into our clinical workflows.