[Research progress on role of microRNA in healing of diabetic wound]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2014 Nov;28(11):1431-4.
[Article in Chinese]

Abstract

Objective: To review the regulatory effect of microRNA (miRNA) in wound healing, which abnormal expression associates with diabetes.

Methods: The literature on miRNA associating with wound healing was reviewed and summarized.

Results: miRNA plays a key role in wound healing, including regulating inflammation, angiogenesis, granulation tissue formation, and re-epithelization.

Conclusion: Abnormal expression of miRNA may be related to delayed healing of the diabetic wound, but further research is needed to confirm it.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / genetics
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / pathology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetes Mellitus, Type 2 / therapy
  • Granulation Tissue
  • Humans
  • Inflammation
  • MicroRNAs / blood
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Wound Healing*

Substances

  • MicroRNAs