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. 2015 Jan;12(1):153-6.
doi: 10.1002/cbdv.201400001.

Two new pyrrolosesquiterpenes produced by a Streptomyces species

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Two new pyrrolosesquiterpenes produced by a Streptomyces species

Dong-Ze Liu et al. Chem Biodivers. 2015 Jan.

Abstract

Two new pyrrolosesquiterpenes, 1 and 2, were isolated from cultures of the soil actinomycete Streptomyces sp. Hd7-21. The structures of these compounds were established as (2Z,4E,9E)-6,7,11-trihydroxy-3,7,11-trimethyl-1-(1H-pyrrol-2-yl)dodeca-2,4,9-trien-1-one (1) and (2Z,4E)-5-{3-[(2E)-4-hydroxy-4-methylpent-2-en-1-yl]-3-methyloxiran-2-yl}-3-methyl-1-(1H-pyrrol-2-yl)penta-2,4-dien-1-one (2) by extensive spectroscopic analyses including MS, and 1D- and 2D-NMR data. Their cytotoxic activities against a panel of human cancer cell lines were evaluated.

Keywords: Actinomycetes; Cytotoxic activity; Pyrrolo-sesquiterpenes; Sesquiterpenes.

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