Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet-induced obesity

Microbiol Immunol. 2015 Feb;59(2):99-103. doi: 10.1111/1348-0421.12226.

Abstract

Mice with diet-induced obesity were fed with Lactobacillus rhamnosus GG (LGG) suspended in saline or saline alone (control mice). Pulmonary mRNA expression of IFN-γ; IFN-α receptor 1; CD247 antigen; killer cell lectin-like receptor subfamily K, member 1; TNF-α; IL-12 receptor β1 and IL-2 receptor β, and the proportion of Lactobacillales in feces were significantly greater in the LGG group than in the control mice (P < 0.05 and P < 0.01, respectively). These results suggest that LGG alters the respiratory immunity of obese subjects through having a potent impact on intestinal immunity.

Keywords: Lactobacillus GG; intestinal microbiota; obesity; respiratory immunity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Cytokines / biosynthesis
  • Diet / methods*
  • Disease Models, Animal
  • Gene Expression Profiling
  • Humans
  • Lacticaseibacillus rhamnosus / immunology*
  • Male
  • Mice, Inbred C57BL
  • Obesity / immunology*
  • Receptors, Immunologic / biosynthesis
  • Respiratory System / immunology*

Substances

  • Cytokines
  • Receptors, Immunologic