Traditional and alternative treatments for depression: implications for migraine management

Headache. 2015 Feb;55(2):351-5. doi: 10.1111/head.12521. Epub 2015 Feb 3.


Background: Migraine is frequently comorbid with major depressive disorder, the presence of which confers increased disability and various clinical challenges.

Methods/results: The present article reviews empirically supported pharmacologic and cognitive-behavioral interventions for depression, as well as the emerging yet generally mixed efficacy for various complementary and alternative medicine depression treatments.

Discussion and conclusion: Clinical implications and treatment strategies for migraine patients with comorbid depression are discussed. The literature reviewed here draws together clinical practice options for clinicians.

Keywords: depression; migraine; psychiatric comorbidity.

Publication types

  • Review

MeSH terms

  • Cognitive Behavioral Therapy
  • Comorbidity
  • Complementary Therapies*
  • Depression / epidemiology
  • Depression / therapy*
  • Disease Management*
  • Humans
  • Migraine Disorders / epidemiology
  • Migraine Disorders / therapy*