What's new in the physiopathology of acne?

Br J Dermatol. 2015 Jul;172 Suppl 1:13-9. doi: 10.1111/bjd.13634.


There are four central factors that contribute to acne physiopathology: the inflammatory response, colonization with Propionibacterium acnes, increased sebum production and hypercornification of the pilosebaceous duct. In addition, research in the areas of diet and nutrition, genetics and oxidative stress is also yielding some interesting insights into the development of acne. In this paper we review some of the most recent research and novel concepts revealed in this work, which has been published by researchers from diverse academic disciplines including dermatology, immunology, microbiology and endocrinology. We discuss the implications of their findings (particularly in terms of opportunities to develop new therapies), highlight interrelationships between these novel factors that could contribute to the pathology of acne, and indicate where gaps in our understanding still exist.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acne Vulgaris / etiology*
  • Acne Vulgaris / genetics
  • Acne Vulgaris / immunology
  • Biofilms
  • Diet / adverse effects
  • Forecasting
  • Gram-Positive Bacterial Infections / physiopathology
  • Humans
  • Immunity, Innate / physiology
  • Oxidative Stress / physiology
  • Propionibacterium acnes / physiology
  • Sebaceous Gland Diseases / complications
  • Sebaceous Gland Diseases / pathology
  • Toll-Like Receptor 2 / metabolism


  • Toll-Like Receptor 2