Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

Respirology. 2015 May;20(4):667-70. doi: 10.1111/resp.12475. Epub 2015 Jan 27.


A sputum eosinophilia is observed in 10-40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling.

Keywords: blood eosinophil; chronic obstructive pulmonary disease; remodelling; reticular basement membrane; submucosal eosinophil.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Basement Membrane / pathology*
  • Biomarkers / blood*
  • Eosinophilia
  • Eosinophils / pathology*
  • Female
  • Humans
  • Leukocyte Count
  • Male
  • Pulmonary Disease, Chronic Obstructive / blood*
  • Pulmonary Disease, Chronic Obstructive / diagnosis*


  • Biomarkers