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Comparative Study
, 14 (2), 288-91

Comparative Analysis of Genome Maintenance Genes in Naked Mole Rat, Mouse, and Human

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Comparative Study

Comparative Analysis of Genome Maintenance Genes in Naked Mole Rat, Mouse, and Human

Sheila L MacRae et al. Aging Cell.

Abstract

Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of CEBPG, a regulator of DNA repair, and TINF2, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long-lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.

Keywords: aging; gene duplication; genome maintenance; longevity; mutation rate.

Figures

Figure 1
Figure 1
Evolution of genome maintenance (GM) and random genes in human, mouse, and naked mole rat (NMR). (A) Nucleotide substitutions per site. (B) Nucleotide substitutions per site (K), per nonsynonymous site (Ka), and per synonymous site (Ks). (C) The ratios of K,Ka, and Ks of GM and random genes in NMR to that in mouse. Abbreviations: H, human; M, mouse; and N, NMR.

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