Developmental biology. Regional identity of gut stem cells--one gene to rule them all

Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):125-6. doi: 10.1038/nrgastro.2015.22. Epub 2015 Feb 3.


The stem cells in the stomach and intestine are regulated by different signalling pathways and give rise to entirely different specialized lineages. A study by Simmini and colleagues suggests that the organ-specific identity of gastrointestinal stem cells is regulated by one transcription factor, Cdx2.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Cellular Reprogramming / genetics*
  • Female
  • Gastric Mucosa / metabolism*
  • Homeodomain Proteins / genetics*
  • Intestinal Mucosa / metabolism*
  • Male
  • Spheroids, Cellular / metabolism*
  • Stem Cells / metabolism*
  • Transcription Factors / genetics*


  • Homeodomain Proteins
  • Transcription Factors