Stress, oxidative injury and disease

Indian J Clin Biochem. 2015 Jan;30(1):3-10. doi: 10.1007/s12291-014-0441-5. Epub 2014 Jun 1.


The living system on earth is largely using oxygen for burning metabolic fuel for energy. The toxicity of oxygen is largely due to the formation of free radicals in living systems. Stress is also responsible for the generation of free radicals. The evidence for the involvement of free radicals and oxidative injury in producing metabolic disturbance, maladjustment and many diseases has been accumulating since long. It is largely believed that the root cause of many chronic diseases is stress induced free radicals and resultant oxidative injury.

Keywords: Free radicals; Oxidative stress; Reactive oxygen species.

Publication types

  • Review