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Observational Study
. 2015 Aug 1;212(3):391-6.
doi: 10.1093/infdis/jiv058. Epub 2015 Feb 2.

Association of Oseltamivir Treatment With Virus Shedding, Illness, and Household Transmission of Influenza Viruses

Doug H Cheung  1 , Tim K Tsang  2 , Vicky J Fang  2 , Jiajing Xu  2 , Kwok-Hung Chan  3 , Dennis K M Ip  2 , Joseph Sriyal Malik Peiris  4 , Gabriel M Leung  2 , Benjamin J Cowling  2
Affiliations
Observational Study

Association of Oseltamivir Treatment With Virus Shedding, Illness, and Household Transmission of Influenza Viruses

Doug H Cheung et al. J Infect Dis. .

Abstract

In an observational study of 582 patients with laboratory-confirmed influenza virus infections and their household contacts, we found that the initiation of oseltamivir within 24 hours was associated with shorter duration of self-reported illness symptoms (56% reduction in duration; 95% confidence interval, 41%-67%). However, we did not find any association of oseltamivir treatment with duration of viral shedding by polymerase chain reaction or with the risk of household transmission.

Keywords: acute respiratory illness; influenza; oseltamivir.

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Figures

Figure A1.
Figure A1.
Time to alleviation of all symptoms (n = 582) (A), fever (n = 474) (B), respiratory symptoms (n = 574) (C), and viral shedding (D) by oseltamivir prescription among index patients with polymerase chain reaction-confirmed influenza virus infection. Note that not all patients had fever or respiratory symptoms at baseline.
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