SOCE in neurons: Signaling or just refilling?

Biochim Biophys Acta. 2015 Sep;1853(9):1940-52. doi: 10.1016/j.bbamcr.2015.01.019. Epub 2015 Jan 31.


In this review we describe the present knowledge about store operated Ca²⁺ entry (SOCE) in neurons and the proteins involved in this process: STIM, as well as Orai and TRP channels. We address the issue of whether SOCE is used only to refill Ca²⁺ in the ER or whether Ca²⁺ that enters the neuronal cell during SOCE also performs signaling functions. We collected the data indicating that SOCE and its components participate in the important processes in neurons. This has implications for identifying new drug targets for the treatment of brain diseases. Evidence indicates that in neurodegenerative diseases Ca²⁺ homeostasis and SOCE components become dysregulated. Thus, different targets and strategies might be identified for the potential treatment of these diseases. This article is part of a Special Issue entitled: 13th European symposium on calcium.

Keywords: Neuron; Orai; STIM; Store operated calcium entry (SOCE); TRPC; Voltage-operated calcium channel.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Diseases / metabolism*
  • Brain Diseases / physiopathology
  • Calcium
  • Calcium Channels / metabolism*
  • Calcium Signaling*
  • Humans
  • Neurodegenerative Diseases / metabolism*
  • Neurodegenerative Diseases / physiopathology
  • Neurons / cytology
  • Neurons / metabolism*


  • Calcium Channels
  • Calcium