Abstract
DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / virology
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Cell Adhesion Molecules / antagonists & inhibitors*
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Cell Adhesion Molecules / chemistry
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Cell Adhesion Molecules / genetics
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Cell Line
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Cells, Cultured
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Dendrimers / chemistry*
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Dendrimers / pharmacology*
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HIV Infections / prevention & control*
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HIV-1 / pathogenicity
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Humans
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Lectins, C-Type / antagonists & inhibitors*
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Lectins, C-Type / chemistry
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Lectins, C-Type / genetics
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Ligands
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Mannose / chemistry
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Receptors, Cell Surface / antagonists & inhibitors*
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / genetics
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Serum Albumin / chemistry
Substances
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Cell Adhesion Molecules
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DC-specific ICAM-3 grabbing nonintegrin
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Dendrimers
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Lectins, C-Type
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Ligands
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Receptors, Cell Surface
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Serum Albumin
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mannose-bovine serum albumin conjugate
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Mannose