Nickel-catalyzed enantioselective C-C bond formation through C(sp2)-O cleavage in aryl esters

Abstract

We report the first enantioselective CC bond formation through CO bond cleavage using aryl ester counterparts. This method is characterized by its wide substrate scope and results in the formation of quaternary stereogenic centers with high yields and asymmetric induction.

Keywords: C-O cleavage; C-O electrophiles; aryl esters; nickel catalysis.