Study of Antiglycation, Hypoglycemic, and Nephroprotective Activities of the Green Dwarf Variety Coconut Water (Cocos nucifera L.) in Alloxan-Induced Diabetic Rats

J Med Food. 2015 Jul;18(7):802-9. doi: 10.1089/jmf.2014.0046. Epub 2015 Feb 4.


Coconut water (CW) is a natural nutritious beverage, which contains several biologically active compounds that are traditionally used in the treatment of diarrhea and rehydration. Several works with CW have been related with antioxidant activity, which is very important in the diabetic state. To evaluate the hypoglycemic and nephroprotective activities of CW, alloxan-induced diabetic rats were pre- and post-treated by gavage with CW (3 mL/kg), caffeic acid (CA) (10 and 15 mg/kg), and acarbose (Acb) (714 μg/kg) during a period of 16 days. Body weight, blood glucose, glycated hemoglobin (HbA1c), and Amadori products in plasma and kidney homogenates were evaluated in all groups and used as parameters for the monitoring of the diabetic state. The results showed that rats of the CW+diabetic group had maintenance in blood glucose compared with the control group (P<.05) in addition to a decrease of HbA1c levels and increase of body weight when compared with the diabetic group rats (P<.05). The animals of the CA and CA+diabetic groups did not have significant variation of body weight (P<.05) during the experiment; however, they showed decrease in their HbA1c and urea levels in plasma as well as Amadori products in kidney homogenates when compared with the diabetic group (P<.05). Our results indicate that CW has multiple beneficial effects in diabetic rats for preventing hyperglycemia and oxidative stress caused by alloxan.

Keywords: antihyperglycemic activity; caffeic acid; coconut water; diabetes; nephroprotective activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acarbose / administration & dosage
  • Alloxan
  • Animals
  • Antioxidants / administration & dosage
  • Beverages*
  • Caffeic Acids / administration & dosage
  • Cocos / chemistry*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetic Nephropathies / prevention & control*
  • Glycated Hemoglobin / analysis
  • Hyperglycemia / prevention & control
  • Hypoglycemic Agents / administration & dosage*
  • Male
  • Oxidative Stress / drug effects
  • Phytotherapy
  • Rats
  • Rats, Wistar
  • Urea / blood


  • Antioxidants
  • Caffeic Acids
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Alloxan
  • Urea
  • Acarbose
  • caffeic acid