NMDA receptor antagonists block norepinephrine-induced long-lasting potentiation and long-term potentiation in rat dentate gyrus

Brain Res. 1989 Mar 20;482(2):351-5. doi: 10.1016/0006-8993(89)91199-2.


In the in vitro rat dentate gyrus, norepinephrine-induced long-lasting potentiation (NELLP) and long-term potentiation (LTP) of responses to perforant path stimulation were blocked by the N-methyl-D-aspartate (NMDA) receptor antagonists, D(-)-2-amino-5-phosphonovaleric acid (D(-)APV) and 3-[(+/-)-2-carboxypiperazin-4-yl]propyl-1-phosphonic acid (CPP). CPP and D(-)APV, but not L(+)APV, also depressed the orthodromic population spike but not the antidromic spike, which suggests that these receptors may function in low-frequency evoked activity of granule cells. We conclude that NELLP, like LTP in the dentate gyrus, requires NMDA receptor activation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate
  • Action Potentials / drug effects
  • Animals
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Male
  • Norepinephrine / pharmacology*
  • Piperazines / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Reaction Time
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / physiology*
  • Valine / analogs & derivatives*
  • Valine / pharmacology


  • Piperazines
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • 2-Amino-5-phosphonovalerate
  • 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
  • Valine
  • Norepinephrine