Th17 cells in autoimmune diseases

Front Med. 2015 Mar;9(1):10-9. doi: 10.1007/s11684-015-0388-9. Epub 2015 Feb 4.


Th17 cells are a new subset of CD4(+) T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, inflammatory bowel disease, and multiple sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases* / immunology
  • Autoimmune Diseases* / physiopathology
  • Autoimmune Diseases* / therapy
  • Cytokines / metabolism
  • Humans
  • Inflammation / immunology*
  • Molecular Targeted Therapy*
  • Protein Processing, Post-Translational / drug effects
  • Th17 Cells / immunology*


  • Cytokines