Autophagy and Neurodegeneration

J Clin Invest. 2015 Jan;125(1):65-74. doi: 10.1172/JCI73944. Epub 2015 Jan 2.

Abstract

Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy*
  • Humans
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / pathology*
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinase Inhibitors / therapeutic use
  • TOR Serine-Threonine Kinases / antagonists & inhibitors

Substances

  • Protein Kinase Inhibitors
  • MTOR protein, human
  • TOR Serine-Threonine Kinases