Uterine cervical cancer with brain metastasis as the initial site of presentation

J Obstet Gynaecol Res. 2015 Jul;41(7):1145-8. doi: 10.1111/jog.12668. Epub 2015 Feb 6.


Brain metastasis from uterine cervical cancer is rare, with an incidence of 0.5%, and usually occurs late in the course of the disease. We report a case of uterine cervical cancer with brain metastasis as the initial site of presentation. A 50-year-old woman with headache, vertigo, amnesia and loss of appetite was admitted for persistent vomiting. Contrast enhanced computed tomography showed a solitary right frontal cerebral lesion with ring enhancement and uterine cervical tumor. She was diagnosed with uterine cervical squamous cell carcinoma with parametrium invasion and no other distant affected organs were detected. The cerebral lesion was surgically removed and pathologically proved to be metastasis of uterine cervical squamous cell carcinoma. The patient underwent concurrent chemoradiotherapy, followed by cerebral radiation therapy, but multiple metastases to the liver and lung developed and the patient died 7 months after diagnosis of brain metastasis.

Keywords: brain metastasis; cervical cancer; chemotherapy; craniotomy; radiotherapy.

Publication types

  • Case Reports

MeSH terms

  • Amnesia / etiology
  • Anorexia / etiology
  • Asymptomatic Diseases / therapy
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / physiopathology
  • Brain Neoplasms / secondary
  • Brain Neoplasms / therapy
  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / physiopathology
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / therapy
  • Combined Modality Therapy
  • Delayed Diagnosis
  • Fatal Outcome
  • Female
  • Head and Neck Neoplasms / diagnosis*
  • Head and Neck Neoplasms / physiopathology
  • Head and Neck Neoplasms / secondary
  • Head and Neck Neoplasms / therapy
  • Headache / etiology
  • Humans
  • Japan
  • Middle Aged
  • Squamous Cell Carcinoma of Head and Neck
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / therapy
  • Vertigo / etiology
  • Vomiting / etiology