Chaos controlled: discovery of a powerful amyloid inhibitor

Mol Cell. 2015 Feb 5;57(3):391-3. doi: 10.1016/j.molcel.2015.01.031.


In this issue of Molecular Cell, Evans et al. (2015) report that the hitherto largely unstudied CsgC protein is responsible for the suppression of premature amyloidogenesis within the cellular periplasm, preventing early aggregation and cellular toxicity.

Publication types

  • Comment

MeSH terms

  • Escherichia coli / genetics*
  • Escherichia coli Proteins / metabolism*
  • Escherichia coli Proteins / pharmacology*
  • Humans
  • Protein Aggregates / drug effects*
  • alpha-Synuclein / metabolism*


  • CsgC protein, E coli
  • Escherichia coli Proteins
  • Protein Aggregates
  • alpha-Synuclein
  • csgA protein, E coli