Ascl2 reinforces intestinal stem cell identity

Cell Stem Cell. 2015 Feb 5;16(2):105-6. doi: 10.1016/j.stem.2015.01.014.


Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5(+) intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers et al. (2015) report an Ascl2 positive feedback loop, tuned by previous Wnt pathway activity, that perpetuates intestinal stem cell identity in response to Wnt/R-spondin stimulation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Intestinal Mucosa / cytology*
  • Intestinal Mucosa / metabolism*
  • Stem Cells / cytology*
  • Stem Cells / metabolism*
  • Thrombospondins / metabolism*
  • Wnt Signaling Pathway*


  • Basic Helix-Loop-Helix Transcription Factors
  • Thrombospondins