A new notch for lung stem cells

Gianni Carraro; Barry R Stripp

doi:10.1016/j.stem.2015.01.012

A new notch for lung stem cells

Cell Stem Cell. 2015 Feb 5;16(2):107-9. doi: 10.1016/j.stem.2015.01.012.

Authors

Gianni Carraro¹, Barry R Stripp²

Affiliations

¹ Departments of Medicine and Biomedical Sciences, Lung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
² Departments of Medicine and Biomedical Sciences, Lung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: barry.stripp@cshs.org.

PMID: 25658364
DOI: 10.1016/j.stem.2015.01.012

Abstract

Homeostasis and repair of different lung compartments require the selective activation of specific progenitor/stem cells and their regulated differentiation to yield cell types that fulfill specialized regional functions. In this issue of Cell Stem Cell, Pardo-Saganta et al. (2015) identify Notch signaling as a determinant of basal cell heterogeneity and fate decisions in pseudostratified airways.

Publication types

Comment

MeSH terms

Animals
Cell Lineage*
Respiratory Mucosa / cytology*
Stem Cells / cytology*
Wounds and Injuries / therapy*