Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32

Genomics. 1989 Apr;4(3):362-6. doi: 10.1016/0888-7543(89)90343-1.

Abstract

Through the use of a cDNA probe, the human erbB-2 gene was localized by in situ hybridization of normal human chromosomes at 17q11-q21. In situ hybridization of chromosomes derived from fibroblasts carrying a constitutional 15;17t(q22.3;q11.21) translocation showed that the erbB-2 gene was relocated on the rearranged chromosome 15. These results as well as grain localization on prophase chromosomes locate the erbB-2 gene at 17q12-q21.32. This localization may facilitate the search for human malignancies with chromosome changes involving the erbB-2 gene.

MeSH terms

  • Base Sequence
  • Cell Line
  • Chromosomes, Human, Pair 15
  • Chromosomes, Human, Pair 17 / ultrastructure*
  • DNA Probes
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • Receptor, ErbB-2
  • Translocation, Genetic

Substances

  • DNA Probes
  • Proto-Oncogene Proteins
  • Receptor, ErbB-2

Associated data

  • GENBANK/J03067