Differential interactions of conjugated polymer nanoparticles with glycosaminoglycans in synthetic urine

Chem Commun (Camb). 2015 Mar 7;51(19):4065-8. doi: 10.1039/c5cc00110b.


Four different conjugated polymer nanoparticles (CPNs) were used to differentiate structurally similar glycosaminoglycans (GAGs) in a urine simulant. Unique emission response patterns of CPNs were analyzed by linear discriminant analysis (LDA), confirming that structurally diverse CPNs are sensitive and effective at differentiating GAGs in a complex biological medium.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Absorption, Physicochemical
  • Biomimetic Materials / chemistry*
  • Glycosaminoglycans / chemistry*
  • Nanoparticles / chemistry*
  • Polymers / chemistry*
  • Urine*


  • Glycosaminoglycans
  • Polymers