raf involvement in the simultaneous genetic transfer of the radioresistant and transforming phenotypes

Int J Radiat Biol. 1989 May;55(5):783-96. doi: 10.1080/09553008914550831.


We examined a human Alu+ mouse tertiary transformant derived from a noncancerous skin fibroblast cell line which exhibits the unique characteristic of being resistant to the killing effects of ionizing radiation. This transformed cell line was found to contain activated human c-raf-1, and demonstrated an increased level of radioresistance indicating the simultaneous transfer of both the transforming and radiation-resistant phenotypes. We have also found a relationship between the presence of activated oncogenes, specifically those with serine/threonine kinase activity and the radioresistant phenotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line, Transformed
  • Humans
  • Mice
  • Oncogenes*
  • Phenotype
  • Radiation Tolerance*
  • Transfection*
  • Transformation, Genetic*