Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord

Neurosci Lett. 1989 Jan 30;96(3):247-52. doi: 10.1016/0304-3940(89)90386-8.


The present study combined the retrograde transport of fluorescent tracers with the immunocytochemical identification of dynorphin A(1-8) in superficial dorsal horn neurons to examine whether peripheral inflammation-induced dynorphin increases are found in local circuit neurons only or also in neurons projecting at least to the caudal mesencephalon. Evidence is presented that complete Freund's adjuvant-induced inflammation produces a large increase in the number of lamina I dynorphin-containing projection and non-projection neurons, and in the number of lamina II dynorphin local circuit neurons.

MeSH terms

  • Animals
  • Cell Count
  • Dynorphins / metabolism*
  • Fluorescent Dyes
  • Immunohistochemistry
  • Inflammation / metabolism*
  • Inflammation / physiopathology
  • Male
  • Peptide Fragments / metabolism*
  • Peripheral Nervous System Diseases / metabolism*
  • Peripheral Nervous System Diseases / physiopathology
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord / metabolism*
  • Spinal Cord / pathology
  • Spinal Cord / physiopathology


  • Fluorescent Dyes
  • Peptide Fragments
  • Dynorphins
  • dynorphin (1-8)