Allogeneic donor availability for hematopoietic stem cell transplantation in children with sickle cell disease

Pediatr Blood Cancer. 2015 Jul;62(7):1285-7. doi: 10.1002/pbc.25439. Epub 2015 Feb 7.


Hematopoietic stem cell transplant is curative of sickle cell disease (SCD) but limited by donor availability. Searches for 85 patients with SCD without matched sibling donors from 2009-2013 using modern techniques (allele-level HLA matching for unrelated donors and higher total nucleated cell doses for umbilical cord blood (UCB)) showed potential match probabilities of 20% for 8/8 HLA-matched unrelated donors, 84% for 7/8 donors, and 97% for two 4-6/6 UCBs suitable for ex-vivo expanded/double cord transplant. Searches performed by age 43 months would have a 90% chance of finding a suitable 5-6/6 UCB.

Keywords: BMT; sickle cell disease; transplantation.

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Sickle Cell / therapy*
  • Child
  • Child, Preschool
  • Computer Simulation
  • Female
  • Fetal Blood*
  • Follow-Up Studies
  • Hematopoietic Stem Cell Transplantation*
  • Histocompatibility Testing*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Monte Carlo Method
  • Prognosis
  • Retrospective Studies
  • Tissue Donors / supply & distribution*
  • Transplantation, Homologous
  • Young Adult