Improvement of erectile function by a combination of French maritime pine bark and roburins with aminoacids

Minerva Urol Nefrol. 2015 Mar;67(1):27-32.


Aim: Primary objective of the study was the evaluation of effects of a combination of plant extracts and aminoacids on erectile function (ED).

Methods: The study was performed as a randomized, placebo-controlled, double-blind, cross-over study. 50 men with moderate ED received a combination of Pycnogenol®, roburins, L-arginine, L-citrulline or placebo. Sexual wellness was evaluated by the International Index of Erectile Function (IIEF).

Results: Treatment over a period of one month restored erectile function to normal.

Conclusion: The combination offers an option for treatment of ED without unwanted effects.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arginine / therapeutic use*
  • Aspartic Acid / therapeutic use*
  • Citrulline / therapeutic use
  • Cross-Over Studies
  • Double-Blind Method
  • Drug Combinations
  • Erectile Dysfunction / drug therapy*
  • Flavonoids / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Penile Erection / drug effects*
  • Phytotherapy* / methods
  • Pinus
  • Plant Extracts / therapeutic use*
  • Quality of Life
  • Quercus
  • Surveys and Questionnaires
  • Tannins / therapeutic use*
  • Treatment Outcome
  • Vasodilator Agents / therapeutic use*


  • Drug Combinations
  • Flavonoids
  • Plant Extracts
  • Tannins
  • Vasodilator Agents
  • prelox
  • Citrulline
  • Aspartic Acid
  • pycnogenols
  • Arginine