Hot water extracts of edible Chrysanthemum morifolium Ramat. exert antidiabetic effects in obese diabetic KK-Ay mice

Biosci Biotechnol Biochem. 2015;79(7):1147-54. doi: 10.1080/09168451.2015.1008975. Epub 2015 Feb 10.


In this study, the antidiabetic effects of a hot water extract of edible Chrysanthemum morifolium Ramat. (HW-ECM) were investigated in type 2 diabetic mice. HW-ECM improved blood glucose levels and insulin resistance and increased adiponectin mRNA expression in adipose tissues and protein concentrations in the plasma. Moreover, it increased adipose mRNA and protein expressions of peroxisome proliferator-activated receptor γ (PPARγ), a regulator of adiponectin transcription, and mRNA expression of its downstream target genes. It also reduced the adipose cell size and attenuated the mRNA expression of pro-inflammatory adipocytokines in adipose tissues. These data presumably indicate a hypoglycemic mechanism of HW-ECM, involving increased PPARγ expression, decreased the adipocyte sizes, and suppression of chronic inflammation in adipose tissues. Finally, elevated adiponectin levels lead to amelioration of insulin resistance and the corresponding hypoglycemic effects. Therefore, HW-ECM indicates its potential as a functional food for type 2 diabetes.

Keywords: Chrysanthemum morifolium Ramat; PPARγ; adiponectin; inflammation; type 2 diabetes.

MeSH terms

  • Adipocytes / drug effects
  • Adiponectin / blood
  • Adiponectin / genetics
  • Adipose Tissue, White / drug effects
  • Adipose Tissue, White / metabolism
  • Animals
  • Blood Glucose / metabolism
  • Body Weight / drug effects
  • Chrysanthemum / chemistry*
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Gene Expression Regulation / drug effects
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Insulin Resistance
  • Male
  • Mice, Obese
  • Organ Size / drug effects
  • PPAR gamma / genetics
  • PPAR gamma / metabolism
  • Panniculitis / genetics
  • Plant Extracts / pharmacology*


  • Adiponectin
  • Adipoq protein, mouse
  • Blood Glucose
  • Hypoglycemic Agents
  • PPAR gamma
  • Plant Extracts