Cu-bearing steel reduce inflammation after stent implantation

J Mater Sci Mater Med. 2015 Feb;26(2):114. doi: 10.1007/s10856-015-5454-y. Epub 2015 Feb 11.


Copper (Cu)-bearing stainless steel with release of Cu2+ ions is a novel material for coronary stents that could reduce the in-stent restenosis after the stent implantation. The inflammation has been recently recognized as an important factor to smooth muscle cells proliferation, thrombosis, and hence the restenosis post-angioplasty. The objective of this study is to further investigate the effect and relevant mechanism of Cu-bearing stainless steel (316L-Cu SS) on the inflammation reaction after stent implantation. The results demonstrated that, compared with commercial coronary stent material (316L SS), 316L-Cu SS could inhibit the inflammation caused by endothelial dysfunction through blockading the inflammatory factors (TNF-α, IL-1β, 6, 8), which would then reduce the recruitment and infiltration of leukocytes, rather than have direct effect on leukocytes. This finding further explained the reduction effect of 316L-Cu SS on in-stent restenosis from a novel view.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloys / chemistry
  • Copper / chemistry*
  • Coronary Restenosis / etiology
  • Coronary Restenosis / immunology*
  • Coronary Restenosis / prevention & control
  • Cytokines / immunology
  • Equipment Failure Analysis
  • Graft Occlusion, Vascular / etiology
  • Graft Occlusion, Vascular / immunology*
  • Graft Occlusion, Vascular / prevention & control
  • Humans
  • Materials Testing
  • Neutrophil Activation / immunology
  • Prosthesis Design
  • Stainless Steel / chemistry*
  • Stents / adverse effects*


  • Alloys
  • Cytokines
  • Stainless Steel
  • Copper