Coffee bean polyphenols ameliorate postprandial endothelial dysfunction in healthy male adults

Int J Food Sci Nutr. 2015 May;66(3):350-4. doi: 10.3109/09637486.2015.1007453. Epub 2015 Feb 10.


To reveal the effect of coffee bean polyphenols (CBPs) on blood vessels, this study aimed to investigate the effect of CBPs on acute postprandial endothelial dysfunction. Thirteen healthy non-diabetic men (mean age, 44.9 ± 1.4 years) consumed a test beverage (active: containing CBPs, placebo: no CBPs) before a 554-kcal test meal containing 14 g of protein, 30 g of fat and 58 g of carbohydrates. Then, a crossover analysis was performed to investigate the time-dependent changes in flow-mediated dilation (FMD) in the brachial artery. In the active group, the postprandial impairment of FMD was significantly improved, the two-hour postprandial nitric oxide metabolite levels were significantly increased and the six-hour postprandial urinary 8-epi-prostaglandin F2α levels were significantly reduced compared to the placebo group. The test meal increased the levels of blood glucose, insulin and triglycerides in both groups with no significant intergroup differences. These findings indicate that CBPs intake ameliorates postprandial endothelial dysfunction in healthy men.

Keywords: Chlorogenic acid; coffee; endothelial function; flow-mediated dilation; nitric oxide; polyphenol.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Brachial Artery / drug effects
  • Brachial Artery / physiopathology
  • Coffea / chemistry
  • Coffee / chemistry*
  • Diet*
  • Dinoprost / analogs & derivatives
  • Dinoprost / urine
  • Double-Blind Method
  • Eating / physiology*
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiopathology
  • Humans
  • Insulin / blood
  • Male
  • Nitric Oxide / blood
  • Polyphenols / pharmacology*
  • Postprandial Period*
  • Reference Values
  • Triglycerides / blood
  • Vasodilation / drug effects*


  • Blood Glucose
  • Coffee
  • Insulin
  • Polyphenols
  • Triglycerides
  • 8-epi-prostaglandin F2alpha
  • Nitric Oxide
  • Dinoprost