Idiopathic gastroparesis

Gastroenterol Clin North Am. 2015 Mar;44(1):59-68. doi: 10.1016/j.gtc.2014.11.015. Epub 2014 Dec 24.


Gastroparesis is a chronic symptomatic disorder of the stomach characterized by delayed emptying without evidence of mechanical obstruction. Idiopathic gastroparesis refers to gastroparesis of unknown cause not from diabetes; not from prior gastric surgery; not related to other endocrine, neurologic, rheumatologic causes of gastroparesis; and not related to medications that can delay gastric emptying. There is overlap in the symptoms of idiopathic gastroparesis and functional dyspepsia. Patients with idiopathic gastroparesis often have a constellation of symptoms including nausea, vomiting, early satiety, postprandial fullness, and upper abdominal pain. Current treatment options of dietary management, prokinetics agents, antiemetic agents, and symptom modulators do not adequately address clinical need for idiopathic gastroparesis.

Keywords: Gastric emptying; Gastroparesis; Idiopathic gastroparesis.

Publication types

  • Review

MeSH terms

  • Combined Modality Therapy
  • Diet Therapy
  • Electric Stimulation Therapy
  • Gastric Emptying / physiology
  • Gastrointestinal Agents / therapeutic use
  • Gastroparesis / diagnosis
  • Gastroparesis / etiology*
  • Gastroparesis / physiopathology
  • Gastroparesis / therapy
  • Humans


  • Gastrointestinal Agents