Creatine phosphokinase elevation exacerbated by levetiracetam therapy

Epilepsy Behav Case Rep. 2014 Oct 22;2:189-91. doi: 10.1016/j.ebcr.2014.09.008. eCollection 2014.


A 19-year-old muscular male with a history of epilepsy presented following two convulsive events. Levetiracetam (LEV) was given as an additional therapy, resulting in a marked boost in creatine phosphokinase (CPK) that could not easily be explained by renal dysfunction or rhabdomyolysis alone. Levetiracetam discontinuation caused CPK levels to quickly normalize and should be considered in patients with persisting CPK elevations postconvulsive seizure.

Keywords: Epilepsy; Muscle; Renal; Rhabdomyolysis; Sarcolemma; Toxicity.