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, 23 (3), 373-9

Is the ``$1000 Genome'' Really $1000? Understanding the Full Benefits and Costs of Genomic Sequencing

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Is the ``$1000 Genome'' Really $1000? Understanding the Full Benefits and Costs of Genomic Sequencing

Kathryn A Phillips et al. Technol Health Care.

Abstract

No abstract available

Keywords: Sequencing; cost-effectiveness; economics; price.

Figures

Figure 1
Figure 1
How Cost-Effectiveness of Genomic Sequencing for Lynch Syndrome in Colorectal Cancer Patients Will Vary Based on Number and Type of Incremental Findings Notes:

- Assumptions: Cost of sequencing = $1000 and prevalence of Lynch syndrome = 3%

- The lifetime discounted consequences of identifying a patient with Lynch among colorectal cancer patients is additional costs of $12,400 and 0.45 additional QALYs (derived from Ladabaum, 2011).

Legend definitions:

- No proven benefit & costly: average cost = $10,000 and average QALY benefit = 0

- Beneficial but costly: average cost = $20,000 and average QALY benefit = 0.1

- Beneficial at moderate cost: average cost = $2,000 and average QALY benefit = 0.1

- Beneficial and cost-saving: average cost = (−)$10,000 and average QALY benefit = 0.1

Figure 2
Figure 2
How Cost-Effectiveness of Genomic Sequencing for Lynch Syndrome in a General Population Will Vary Based on Number and Type of Incremental Findings Notes:

- Assumptions: Cost of sequencing = $1000 and prevalence of Lynch syndrome = 0.25%

- The lifetime discounted consequences of identifying a patient with Lynch among persons in the general population is additional costs of $8,500 and 0.61 additional QALYs (derived from Ladabaum, 2011).

Legend definitions:

- No proven benefit & costly: average cost = $10,000 and average QALY benefit = 0

- Beneficial but costly: average cost = $20,000 and average QALY benefit = 0.1

- Beneficial at moderate cost: average cost = $2,000 and average QALY benefit = 0.1

- Beneficial and cost-saving: average cost = (−)$10,000 and average QALY benefit = 0.1

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