Recombinant human C1 esterase inhibitor for the treatment of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE)

Expert Rev Clin Immunol. 2015 Mar;11(3):319-27. doi: 10.1586/1744666X.2015.1012502. Epub 2015 Feb 10.


The lack of C1 inhibitor function that results in excessive production of bradykinin causing the angioedema seen in hereditary angioedema (HAE) is well established. Several drugs have been developed to treat and prevent attacks in patients suffering from HAE due to C1 inhibitor deficiency (C1-INH-HAE). Plasma-derived C1INH has been used to replace the deficiency of C1 inhibitor (C1INH) and has been approved for both treatment of attacks and for prophylactic therapy to prevent attacks. Plasma kallikrein inhibitor (ecallantide) and bradykinin receptor antagonist (icatibant) are both effective for treatment of acute attacks, but their short half-life limits the use for prophylaxis. Androgens, in particular danazol, are effective for long-term prophylaxis, but adverse event profile can limit its use. Recombinant C1 inhibitor derived from transgenic rabbits has recently been approved for use in treatment of C1-INH-HAE attacks and is effective and appears safe with minimal adverse event profile.

Keywords: C1 inhibitor; C1-esterase inhibitor; hereditary angioedema; recombinant; recombinant C1 inhibitor; treatment.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Angioedemas, Hereditary / drug therapy*
  • Animals
  • Animals, Genetically Modified
  • Clinical Trials as Topic
  • Complement C1 Inhibitor Protein / therapeutic use*
  • Humans
  • Rabbits
  • Recombinant Proteins / therapeutic use*


  • Complement C1 Inhibitor Protein
  • Recombinant Proteins