A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety

Psychopharmacology (Berl). 1989;97(2):277-9. doi: 10.1007/BF00442264.


We examined the anxiolytic effects of a variety of anti-depressant drugs, administered either acutely or chronically, in an animal model of anxiety involving novelty-suppressed feeding in food-deprived rats. Following a single injection of desipramine (10 mg/kg) amitriptyline (10 mg/kg), mianserin (10 mg/kg), fluoxetine (10 mg/kg), buspirone (4 mg/kg), gepirone (4 mg/kg) or nomifensine (10 mg/kg), there was no decrease in the latency to begin eating in the novel environment such as occurred with diazepam (2 mg/kg). In fact, an increased latency was observed for desipramine, amitriptyline, fluoxetine, and nomifensine. In contrast, chronic (21 days) treatment with each of the above-mentioned drugs, except nomifensine, significantly reduced the latency to begin eating relative to vehicle controls. These findings suggest that a variety of tricyclic and novel anti-depressant drugs acquire anxiolytic properties following chronic administration.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Anxiety Agents*
  • Antidepressive Agents / pharmacology*
  • Diazepam / pharmacology*
  • Environment
  • Feeding Behavior / drug effects
  • Male
  • Rats


  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Diazepam