The expression of Fcγ receptors in Hashimoto's thyroiditis

Cell Immunol. 2015 Mar;294(1):33-8. doi: 10.1016/j.cellimm.2015.01.016. Epub 2015 Feb 3.

Abstract

The pathophysiological mechanism underlying Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) are diagnostic hallmarks of HT. These IgG antibodies regulate the balance of immunologic tolerance and autoimmunity via Fcγ receptors (FcγRs). The aim of our study was to investigate the role of FcγRs in the pathogenesis of HT. The percentage of peripheral blood mononuclear cells (PBMCs) from HT patients bearing FcγRII was significantly lower than that seen in healthy donors, and the mean fluorescence intensity (MFI) value of FcγRII on PBMCs from HT patients was significantly higher. The percentage of PBMCs positive for FcγRIII also was significantly higher in HT patients, and the percentage of B cells bearing FcγRIIB in HT patients was significantly lower than that seen in healthy donors. Our study therefore provides evidence for FcγRs, especially FcγRIIB, being involved in the pathogenesis of HT.

Keywords: B cells; FcγRIIB; FcγRs; Hashimoto’s thyroiditis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / immunology
  • Antibodies, Monoclonal / immunology
  • Antibody Specificity / immunology
  • Autoantigens / immunology
  • Autoimmunity / immunology
  • B-Lymphocytes / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hashimoto Disease / immunology*
  • Humans
  • Iodide Peroxidase / immunology
  • Iron-Binding Proteins / immunology
  • Leukocytes, Mononuclear / immunology*
  • Male
  • Middle Aged
  • Receptors, IgG / immunology*
  • Thyroglobulin / immunology
  • Young Adult

Substances

  • Antibodies, Monoclonal
  • Autoantigens
  • Fc gamma receptor IIB
  • Iron-Binding Proteins
  • Receptors, IgG
  • Thyroglobulin
  • TPO protein, human
  • Iodide Peroxidase