Triphenylarsonium-functionalised gold nanoparticles: potential nanocarriers for intracellular therapeutics

Chem Commun (Camb). 2015 Mar 7;51(19):4109-11. doi: 10.1039/c4cc09304f.

Abstract

Two new triphenylarsonium alkylthiolate precursors, a thiosulfate zwitterion and a thioacetate salt, have been structurally characterised and their cytotoxicity evaluated against PC3 cells. The arsonium compounds have been used to prepare gold nanoparticles decorated with triphenylarsonium groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arsenicals / chemistry*
  • Arsenicals / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Carriers / chemistry*
  • Gold / chemistry*
  • Humans
  • Intracellular Space / drug effects*
  • Metal Nanoparticles / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Sulfates / chemistry

Substances

  • Arsenicals
  • Drug Carriers
  • Sulfates
  • Gold