Pharmacokinetic considerations for drugs administered in the critically ill

Br J Hosp Med (Lond). 2015 Feb;76(2):89-94. doi: 10.12968/hmed.2015.76.2.89.

Abstract

Significant physiological changes are common among critically ill patients. This case-based review describes the consequences of these changes on the selection and dosing of medications.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / metabolism*
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use
  • Anticoagulants / pharmacokinetics
  • Anticoagulants / therapeutic use
  • Critical Illness*
  • Drug Interactions
  • Fluid Shifts
  • Fluid Therapy*
  • Heparin, Low-Molecular-Weight / pharmacokinetics
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Humans
  • Hypotension / therapy*
  • Male
  • Middle Aged
  • Pneumonia, Bacterial / drug therapy*
  • Protein Binding
  • Serum Albumin / metabolism*
  • Venous Thromboembolism / prevention & control

Substances

  • Anti-Bacterial Agents
  • Anticoagulants
  • Heparin, Low-Molecular-Weight
  • Serum Albumin