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. 2015 Apr;33(4):1965-75.
doi: 10.3892/or.2015.3792. Epub 2015 Feb 10.

OY-TES-1 May Regulate the Malignant Behavior of Liver Cancer via NANOG, CD9, CCND2 and CDCA3: A Bioinformatic Analysis Combine With RNAi and Oligonucleotide Microarray

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OY-TES-1 May Regulate the Malignant Behavior of Liver Cancer via NANOG, CD9, CCND2 and CDCA3: A Bioinformatic Analysis Combine With RNAi and Oligonucleotide Microarray

Qiping Hu et al. Oncol Rep. .

Abstract

Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis combined with RNA interference (RNAi) and oligonucleotide microarray, we report for the first time that downregulation of OY-TES-1 resulted in significant changes in expression of NANOG, CD9, CCND2 and CDCA3 in the liver cancer cell line BEL-7404. NANOG, CD9, CCND2 and CDCA3 may be involved in cell proliferation, migration, invasion and apoptosis, yet also may be functionally related to each other and OY-TES-1. Among these molecules, we identified that NANOG, containing a Kazal-2 binding motif and homeobox, may be the most likely candidate protein interacting with OY-TES-1 in liver cancer. Thus, the present study may provide important information for further investigation of the roles of OY-TES-1 in liver cancer.

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