Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis

Tae Young Han; Tae Seok Kong; Min Ho Kim; Jeong Don Chae; June Hyun Kyung Lee; Sook-Ja Son

doi:10.5021/ad.2015.27.1.10

Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis

Ann Dermatol. 2015 Feb;27(1):10-4. doi: 10.5021/ad.2015.27.1.10. Epub 2015 Feb 3.

Authors

Tae Young Han¹, Tae Seok Kong¹, Min Ho Kim², Jeong Don Chae³, June Hyun Kyung Lee¹, Sook-Ja Son¹

Affiliations

¹ Department of Dermatology, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.
² Eulji Medi-Bio Research Institute, Eulji University, Seoul, Korea. ; Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul, Korea.
³ Department of Laboratory Medicine, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.

Abstract

Background: Vitamin D insufficiency could be associated with the prevalence of atopic dermatitis (AD).

Objective: To examine vitamin D status and the relations between serum 25-hydroxyvitamin D levels, SCORAD score, serum LL-37 level, and body mass index (BMI) in Korean AD patients, and to explore whether these associations differ between adults and children.

Methods: Serum 25-hydroxyvitamin D levels, serum LL-37, and clinical features were analyzed in a total of 72 Korean patients with AD (39 adults and 33 children) and 140 healthy control subjects (70 adults and 70 children).

Results: Serum 25-hydroxyvitamin D levels were significantly reduced in children with AD (15.06±4.64 ng/ml) compared with normal children in the control group (16.25±6.60 ng/ml) (p=0.036). Significant inverse correlations were found between BMI and 25-hydroxyvitamin D level (r=-0.315, p=0.007) and between the SCORAD score and serum LL-37 level (r=-0.3, p=0.011) in the total AD patients.

Conclusion: The results showed that serum vitamin D levels were lower in children with AD than in healthy children; however, the same relation was not observed between adults with AD and healthy adults. Serum 25-hydroxyvitamin D concentration was not significantly correlated with AD severity or serum LL-37 levels in our study population.

Keywords: 25-Hydroxyvitamin D; Atopic dermatitis; LL-37; SCORAD.