Double trouble: HIV latency and CTL escape

Cell Host Microbe. 2015 Feb 11;17(2):141-2. doi: 10.1016/j.chom.2015.01.008.


HIV can enter a state of latency that allows it to persist for decades in antiretroviral drug-treated patients. In a recent Nature paper, Deng et al. (2015) show that this latent reservoir also contains a large number of cytotoxic T lymphocyte escape mutants, presenting another challenge to HIV cure efforts.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Female
  • Genes, Dominant / genetics*
  • Genes, Viral / genetics*
  • HIV-1 / genetics*
  • HIV-1 / immunology*
  • Humans
  • Male
  • Mutation / genetics*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Virus Latency / immunology*