Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America

J Tweedy; M A Spyrou; C D Donaldson; D Depledge; J Breuer; U A Gompels

doi:10.1128/genomeA.01498-14

Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America

Genome Announc. 2015 Feb 12;3(1):e01498-14. doi: 10.1128/genomeA.01498-14.

Authors

J Tweedy¹, M A Spyrou¹, C D Donaldson², D Depledge², J Breuer², U A Gompels³

Affiliations

¹ Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.
² MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom.
³ Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom ursula.gompels@lshtm.ac.uk.

Abstract

The genome sequence of human herpesvirus 6A (HHV-6A) strain AJ was determined in a comparison of target enrichment and long-range PCR using next-generation sequencing methodologies. The analyses show 85 predicted open reading frames (ORFs), conservation with sequenced HHV-6A reference strain U1102, and closest identity to the recently determined GS strain, despite different geographic origins (United States and Gambia).