The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

Metabolism. 2015 Jul;64(7):793-6. doi: 10.1016/j.metabol.2015.01.010. Epub 2015 Jan 28.


Background: There are no previous data on the association of PNPLA3 I148M polymorphism (rs738409) with circulating adipokines and myokines in children.

Subjects/methods: Subjects were a population sample of 481 Caucasian children aged 6-8 years. We assessed circulating levels of irisin together with IL-6, TNF-α, leptin, high molecular weight (HMW)-adiponectin, alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) while the subjects were stratified according to PNPLA3 I148M variants.

Results: The PNPLA3 rs738409 polymorphism had a linear relationship with plasma levels of irisin after adjustment for age, sex and body height (p=0.007) but it was not associated with circulating levels of interleukin- 6 (IL-6), tumor-necrosis factor α (TNF-α), leptin or HMW-adiponectin.

Conclusion: PNPLA3 148M allele carriers had higher plasma levels of irisin than the non-carriers. This might be due to compensatory mechanism to limit early steatotic and inflammatory changes in the liver.

Keywords: Children; Irisin; PNPLA3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines / blood
  • Alanine Transaminase / blood
  • Alleles
  • Child
  • Female
  • Fibronectins / blood*
  • Genotype
  • Humans
  • Interleukin-6 / blood
  • Leptin / blood
  • Lipase / genetics*
  • Male
  • Membrane Proteins / genetics*
  • Polymorphism, Genetic / genetics
  • Risk Factors
  • Tumor Necrosis Factor-alpha / blood
  • White People / genetics*
  • gamma-Glutamyltransferase / blood


  • Adipokines
  • FNDC5 protein, human
  • Fibronectins
  • IL6 protein, human
  • Interleukin-6
  • Leptin
  • Membrane Proteins
  • Tumor Necrosis Factor-alpha
  • gamma-Glutamyltransferase
  • Alanine Transaminase
  • Lipase
  • adiponutrin, human