Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross

M F Seldin; G D Kruh

doi:10.1016/0888-7543(89)90305-4

Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross

Genomics. 1989 Feb;4(2):221-3. doi: 10.1016/0888-7543(89)90305-4.

Authors

M F Seldin¹, G D Kruh

Affiliation

¹ Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.

PMID: 2567701
DOI: 10.1016/0888-7543(89)90305-4

Abstract

A human Abelson related gene (ABLL) cDNA clone was used to detect restriction fragment length polymorphisms (RFLPs) on mouse Southern blots. Abll was mapped to mouse chromosome 1 by analysis of segregation with other distal chromosome 1 genetic polymorphisms by using a panel of DNAs from [(C3H/HeJ-gld/gld x Mus spretus) F1 x C3H/HeJ-gld/gld] interspecific backcross mice. The data indicate the following gene order: (centromere)-CD45-6.5 cM-Lamb-2-1 cM-Abll-2 cM-At-3. The results extend the analysis of a large conserved linkage group spanning nearly 30 cM on distal mouse chromosome 1 syntenic with human chromosome 1q21-32. Within this linkage group similar relative positions have been characterized in both species for C4BP, REN, CD45, LAMB2, ABLL, AT3, APOA2, and SPTA.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosome Mapping
Chromosomes, Human, Pair 1*
Crosses, Genetic
Humans
Mice
Mice, Inbred Strains / genetics*
Muridae / genetics*
Polymorphism, Restriction Fragment Length